Iron oxide nanoparticles stabilized with a bilayer of oleic acid for magnetic hyperthermia and MRI applications

TitleIron oxide nanoparticles stabilized with a bilayer of oleic acid for magnetic hyperthermia and MRI applications
Publication TypeJournal Article
Year of Publication2016
AuthorsSoares PIP a, Laia CAT b, Carvalho A a, Pereira LCJ c, Coutinho JT c, Ferreira IMM a, Novo CMM d, Borges JP a
JournalApplied Surface Science
Volume383
Pagination240-247
ISSN01694332
KeywordsAcid concentrations, Biocompatibility, Biocompatible surfactants, Biomedical applications, Colloidal Stability, High resolution transmission electron microscopy, Hydrodynamic diameter, Iron, Iron oxide nanoparticle, Iron oxides, Magnetic hyperthermia, Magnetic resonance imaging, Magnetism, Medical applications, Metal nanoparticles, Nanomagnetics, Nanoparticles, Oleic acid, Physiological condition, Transmission electron microscopy
Abstract

Iron oxide nanoparticles (Fe3O4, IONPs) are promising candidates for several biomedical applications such as magnetic hyperthermia and as contrast agents for magnetic resonance imaging (MRI). However, their colloidal stability in physiological conditions hinders their application requiring the use of biocompatible surfactant agents. The present investigation focuses on obtaining highly stable IONPs, stabilized by the presence of an oleic acid bilayer. Critical aspects such as oleic acid concentration and pH were optimized to ensure maximum stability. NPs composed of an iron oxide core with an average diameter of 9 nm measured using transmission electron microscopy (TEM) form agglomerates with an hydrodynamic diameter of around 170 nm when dispersed in water in the presence of an oleic acid bilayer, remaining stable (zeta potential of -120 mV). Magnetic hyperthermia and the relaxivities measurements show high efficiency at neutral pH which enables their use for both magnetic hyperthermia and MRI. © 2016 Elsevier B.V. All rights reserved.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84966277057&doi=10.1016%2fj.apsusc.2016.04.181&partnerID=40&md5=22811619aaf3d95dd0e93c091b2db806
DOI10.1016/j.apsusc.2016.04.181