Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release

TitleTowards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release
Publication TypeJournal Article
Year of Publication2016
AuthorsSoares PIP a, Sousa AI a, Ferreira IMM a, Novo CMM b, Borges JP a
JournalCarbohydrate Polymers
Volume153
Pagination212-221
ISSN01448617
KeywordsChitin, Chitosan, Composite materials, Composite nanoparticles, Doxorubicin, Drug delivery, Drug delivery system, Hydrodynamic diameter, Iron, Iron oxide nanoparticle, Iron oxides, Mathematical models, Metal nanoparticles, Nanomagnetics, Nanometric ranges, Nanoparticles, Polymeric nanoparticles, Release mechanism, Synthesis (chemical)
Abstract

In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion. © 2016 Elsevier Ltd

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84979951018&doi=10.1016%2fj.carbpol.2016.07.109&partnerID=40&md5=193d8340f3a053838eb9da37b92d42dc
DOI10.1016/j.carbpol.2016.07.109