%0 Journal Article %J Carbohydrate Polymers %D 2016 %T Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release %A Soares, P.I.P.a %A Sousa, A.I.a %A Ferreira, I.M.M.a %A Novo, C.M.M.b %A Borges, J.P.a %I Elsevier Ltd %K Chitin %K Chitosan %K Composite materials %K Composite nanoparticles %K Doxorubicin %K Drug delivery %K Drug delivery system %K Hydrodynamic diameter %K Iron %K Iron oxide nanoparticle %K Iron oxides %K Mathematical models %K Metal nanoparticles %K Nanomagnetics %K Nanometric ranges %K Nanoparticles %K Polymeric nanoparticles %K Release mechanism %K Synthesis (chemical) %P 212-221 %R 10.1016/j.carbpol.2016.07.109 %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979951018&doi=10.1016%2fj.carbpol.2016.07.109&partnerID=40&md5=193d8340f3a053838eb9da37b92d42dc %V 153 %X In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion. © 2016 Elsevier Ltd %Z cited By 1