<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Soares, P.I.P.a</style></author><author><style face="normal" font="default" size="100%">Sousa, A.I.a</style></author><author><style face="normal" font="default" size="100%">Ferreira, I.M.M.a</style></author><author><style face="normal" font="default" size="100%">Novo, C.M.M.b</style></author><author><style face="normal" font="default" size="100%">Borges, J.P.a</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release</style></title><secondary-title><style face="normal" font="default" size="100%">Carbohydrate Polymers</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chitin</style></keyword><keyword><style  face="normal" font="default" size="100%">Chitosan</style></keyword><keyword><style  face="normal" font="default" size="100%">Composite materials</style></keyword><keyword><style  face="normal" font="default" size="100%">Composite nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">Doxorubicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug delivery</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug delivery system</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrodynamic diameter</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron oxide nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron oxides</style></keyword><keyword><style  face="normal" font="default" size="100%">Mathematical models</style></keyword><keyword><style  face="normal" font="default" size="100%">Metal nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanomagnetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanometric ranges</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymeric nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">Release mechanism</style></keyword><keyword><style  face="normal" font="default" size="100%">Synthesis (chemical)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979951018&amp;doi=10.1016%2fj.carbpol.2016.07.109&amp;partnerID=40&amp;md5=193d8340f3a053838eb9da37b92d42dc</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">Elsevier Ltd</style></publisher><volume><style face="normal" font="default" size="100%">153</style></volume><pages><style face="normal" font="default" size="100%">212-221</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion. © 2016 Elsevier Ltd</style></abstract><notes><style face="normal" font="default" size="100%">cited By 1</style></notes></record></records></xml>